Compounds studied for skin & aesthetic, ranked by the strength of the evidence — strongest at the top, research-grade and disappointing below. Grades reflect the evidence, not marketing. This is a neutral reference; nothing here is a recommendation to use, and no compound is offered for sale.
Matrixyl (INCI Palmitoyl Pentapeptide-4) is a synthetic signal peptide — a palmitoylated fragment (Pal-KTTKS) of type I procollagen — used in anti-ageing cosmetics.
AHK-Cu is a copper-binding tripeptide engineered for hair (whereas GHK-Cu targets skin).
Argireline (INCI Acetyl Hexapeptide-8) is a synthetic six-amino-acid cosmetic peptide, a fragment of SNAP-25, popularly marketed as "topical botox." Small human studies suggest a…
Melanotan II is a non-selective melanocortin agonist — the original "tanning peptide." It genuinely does induce a tan (and arousal), but it is not approved anywhere, sits in FDA…
Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tripeptide-5 (Pal-KVK / SYN-COLL) are signal peptides proposed, like Matrixyl, to tell skin fibroblasts to make collagen —…
SNAP-8 (Acetyl Octapeptide-3) is an elongated version of Argireline that works through the same SNARE / SNAP-25 mechanism and is marketed as a more potent "topical botox." Its…
Ranking is by evidence grade (A–F), the same ceiling shown on each compound page — not by popularity or margin. No dosing, reconstitution, or administration is given anywhere on Vallydia. See each entry for its full evidence table and legal status by region.
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This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia SL — Registered in Spain.