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Explore  /  Dihydroquercetin (Taxifolin)
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Dihydroquercetin (Taxifolin)

D
lead outcome
Topical antioxidant / anti-aging appearance…
grades vary by outcome ↓
Small molecule (non-peptide)
also called — Dihydroquercetin · Taxifolin · (2R,3R)-taxifolin (flavanonol, from larch and conifers) · INCI: Taxifolin
skin appearance (cosmetic)antioxidant(in-vitro:) capillary-protective
In brief

Dihydroquercetin (taxifolin) is a flavanonol — the dihydro form of quercetin — extracted mainly from larch and conifers, with a strong in-vitro antioxidant profile and reported capillary-stabilising activity. That laboratory pharmacology is why it appears in some antioxidant cosmetic formulations. But the topical picture for skin is thin: little controlled human evidence, and the usual questions of penetration and formulation. Much of the broader taxifolin literature concerns ingestible use, outside this topical register's scope. A genuinely capable antioxidant molecule with little cosmetic clinical evidence behind the skincare framing.

Legal standing, by region
European Union
Lawful cosmetic ingredient

Taxifolin (INCI) can be used as a cosmetic ingredient; claims must remain appearance-based. Also sold as an ingestible supplement — outside this register's topical scope.

International
Lawful cosmetic ingredient

Used as a plant-flavonoid antioxidant (often from Siberian larch) in some formulations; rules vary.

Evidence, by outcome
How we grade →

An honest grade per outcome — drawn from the evidence, not any catalogue. Hype and undemonstrated marketing claims grade low.

OutcomeEvidence base · effectGrade
Topical antioxidant / anti-aging appearance (human)
The by-now-familiar gap: strong antioxidant chemistry, minimal evidence on real skin.
Little controlled human topical data. Cosmetic interest rests on in-vitro antioxidant and capillary/microcirculation-related mechanistic work, not clinical skin trials. · Not established on human skin.
D
Antioxidant / capillary-protective (mechanism)
Grades the MECHANISM only. Penetration and stability in a cosmetic formulation are the limiting questions.
A flavanonol (dihydro form of quercetin) with well-described in-vitro antioxidant, radical-scavenging and reported capillary-stabilising activity. · Consistent antioxidant activity in the lab.
C
Tolerability / formulation
Better water solubility than some flavonols, but independent cosmetic safety and efficacy data are limited.
Limited cosmetic-use data · Reported well tolerated
Disclosure

Vallydia sells its own cosmetic serums, and some ingredients graded here belong to the same categories as those products. Grades are drawn from the published evidence by the method we publish, and applied to our own ingredients on the same terms — our copper-peptide serum is graded no more kindly than the peptides it competes with. We disclose the interest so you can weigh it.

Trade names shown here (for example Matrixyl, Argireline, Syn-Ake) are the property of their respective owners and are used only to identify the ingredient under discussion. Their appearance implies no affiliation with, or endorsement by, the proprietor.

Evidence changes

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Cosmetic claims boundary
✓ Allowed (appearance / feel)
  • antioxidant support for the look of protected skin
  • a plant-flavonoid antioxidant within a routine
✕ Not allowed (medicinal)
  • treats aging
  • reverses wrinkles
  • treats redness / rosacea
  • strengthens capillaries
  • anti-inflammatory treatment

The medicinal-sounding science stays in the reference section; product copy speaks only to appearance/feel (Reg 655/2013). Different fields, never merged.

The honest part

Dihydroquercetin/taxifolin is a cosmetic ingredient framed around antioxidant support. Its in-vitro antioxidant activity is real, but controlled human topical evidence is minimal, and penetration and formulation are the limiting questions. Much of the interest around taxifolin concerns ingestible supplement use, which is outside this register's topical scope. Claims should stay modest and appearance-based, and it complements — never replaces — sunscreen.

Identity

Dihydroquercetin — more precisely taxifolin — is a flavanonol, the dihydro (saturated) form of the well-known flavonol quercetin. It is extracted mainly from larch (notably Siberian larch) and other conifers. In cosmetics it is used under the INCI name Taxifolin as a plant-flavonoid antioxidant. (Like its flavonoid cousins, it is also sold as an ingestible supplement — outside this register's topical scope.)

Mechanism (as proposed)

Taxifolin is a strong in-vitro antioxidant and radical scavenger, and is reported to have capillary-stabilising (microcirculation-protective) activity — the basis of some "anti-redness" and "vascular support" cosmetic positioning. The antioxidant chemistry is genuine. As with the other plant flavonoids in this register, the honest limits are delivery-side: penetration through intact skin and stability in formulation determine how much of the lab activity actually reaches living tissue.

Reading the evidence honestly

The missing piece is the same as for myricetin and mangiferin: little controlled human topical data for any skin outcome. The cosmetic case rests on in-vitro antioxidant and capillary-related results, and antioxidant potency in a dish translates unreliably to visible skin benefit — hence the D grade despite a capable laboratory profile. The larger taxifolin evidence base concerns ingestible use, which this topical register does not cover.

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Chemical identifiers

Cross-reference identifiers for the authoritative external databases — not a recipe, and nothing about how to use it.

PubChem CID439533
InChIKeyCXQWRCVTCMQVQX-LSDHHAIUSA-N

via PubChem CID 439533 — InChIKey and formula (C15H12O7) verified. · verified confidence

Sources — 3 cited
01In-vitro and mechanistic literature on taxifolin/dihydroquercetin antioxidant and capillary-stabilising activity.
02Reviews of flavonoid antioxidants in cosmetic formulation.
03resolve:required — verify any topical human citation before publishing; current evidence appears in-vitro-dominant.
Updated 2026-08-07

Grades reflect the published evidence, not our interest. No dosing, reconstitution, or administration is published for research compounds — that restraint is deliberate.

Related compounds
Ferulic AcidB
Small molecule (non-peptide)
MyricetinD
Small molecule (non-peptide)
NaringeninB
Small molecule (non-peptide)
Green Tea (Camellia Sinensis)B
Blend / combination
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Skin & aesthetic
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This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia.