Compounds studied for longevity & cellular, ranked by the strength of the evidence — strongest at the top, research-grade and disappointing below. Grades reflect the evidence, not marketing. This is a neutral reference; nothing here is a recommendation to use, and no compound is offered for sale.
Glutathione (GSH) is a tripeptide that serves as the body's master antioxidant — genuinely essential intracellular chemistry.
NAD⁺ is a fundamental coenzyme (not a peptide) that powers energy metabolism, DNA repair, and the sirtuin "longevity" enzymes — and declines with age, which is the basis of a…
Rapamycin (sirolimus) is a small-molecule mTOR inhibitor — and longevity science's flagship.
SS-31 (elamipretide) is a mitochondria-targeting tetrapeptide that binds cardiolipin and stabilises the inner-membrane machinery that produces cellular energy.
Dasatinib+Quercetin (D+Q) and Fisetin are the first and best-known senolytics — drugs that selectively kill senescent "zombie" cells, which accumulate with age and pump out an…
Epitalon is a synthetic tetrapeptide (AEDG) from Russian pineal-peptide research, heavily promoted for telomerase activation and longevity.
Humanin is the founding mitochondrial-derived peptide — a 24-amino-acid signal encoded in mitochondrial DNA, discovered in 2001 from an Alzheimer's-resistant neuron.
Resveratrol is a stilbenoid antioxidant from grapes and Japanese knotweed, famous from the ingestible "longevity/SIRT1" story — most of which is cell, animal and supplement…
Thymalin is a calf-thymus polypeptide complex and the founding compound of the Soviet/Russian "peptide bioregulator" school — the program (Khavinson & Morozov, 1970s) that also…
FOXO4-DRI is a synthetic senolytic peptide — it doesn't boost a pathway like NAD⁺; it selectively kills "zombie" (senescent) cells, the worn-out non-dividing cells that…
Methylene blue is three different things wearing one name.
Epithalamin is a polypeptide extract of bovine pineal gland, developed from the 1970s by Vladimir Khavinson and colleagues at the St Petersburg Institute of Bioregulation and…
The Khavinson peptide bioregulators are a family of very short peptides — typically two to four amino acids — developed since the 1970s at the St Petersburg Institute of…
Klotho (α-Klotho) is a genuine longevity protein in the strict sense: disrupting its gene in mice produces an accelerated ageing syndrome, and overexpressing it extends mouse…
PNC-27 is a synthetic peptide combining a fragment of the tumour-suppressor protein p53 with a membrane-penetrating sequence, reported by its originating groups to kill cancer…
Ranking is by evidence grade (A–F), the same ceiling shown on each compound page — not by popularity or margin. No dosing, reconstitution, or administration is given anywhere on Vallydia. See each entry for its full evidence table and legal status by region.
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This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia.