Compounds studied for mitochondrial, ranked by the strength of the evidence — strongest at the top, research-grade and disappointing below. Grades reflect the evidence, not marketing. This is a neutral reference; nothing here is a recommendation to use, and no compound is offered for sale.
NAD⁺ is a fundamental coenzyme (not a peptide) that powers energy metabolism, DNA repair, and the sirtuin "longevity" enzymes — and declines with age, which is the basis of a…
SS-31 (elamipretide) is a mitochondria-targeting tetrapeptide that binds cardiolipin and stabilises the inner-membrane machinery that produces cellular energy.
Humanin is the founding mitochondrial-derived peptide — a 24-amino-acid signal encoded in mitochondrial DNA, discovered in 2001 from an Alzheimer's-resistant neuron.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide, encoded in mtDNA and discovered in 2015, that regulates metabolism largely through the AMPK pathway.
ATX-304 is a direct pan-AMPK activator — it switches on AMP-activated protein kinase, the cell's central energy sensor, turning up fat-burning and glucose uptake and turning down…
BAM15 is a mitochondrial uncoupler — a protonophore that dissipates the proton gradient across the inner mitochondrial membrane, so energy is released as heat instead of stored…
Methylene blue is three different things wearing one name.
Apelin is an endogenous peptide and the natural ligand of the APJ receptor, a G-protein-coupled receptor closely related to the angiotensin II receptor.
SLU-PP-332 is a small-molecule ERR (estrogen-related receptor) agonist — an "exercise mimetic" designed to switch on the muscle's aerobic-exercise gene program without exercise.
SLU-PP-915 is a small-molecule pan-ERR agonist — an "exercise mimetic" — and the orally-active successor to SLU-PP-332 (#60) from the same lab (Thomas Burris).
Ranking is by evidence grade (A–F), the same ceiling shown on each compound page — not by popularity or margin. No dosing, reconstitution, or administration is given anywhere on Vallydia. See each entry for its full evidence table and legal status by region.
A neutral reference and a lawful-lane shop. Information for those who seek it — never promotion.
This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia.