Compounds studied for sleep & circadian, ranked by the strength of the evidence — strongest at the top, research-grade and disappointing below. Grades reflect the evidence, not marketing. This is a neutral reference; nothing here is a recommendation to use, and no compound is offered for sale.
VIP is a 28-amino-acid endogenous neuropeptide with broad, well-established physiology — it's a potent vasodilator and bronchodilator, a strong anti-inflammatory/immune…
MK-677 (ibutamoren) is an oral, non-peptide ghrelin-receptor agonist — the pill version of the injectable GHRPs.
DSIP (regulatory name Emideltide) is a naturally occurring nonapeptide named for its ability to promote delta (deep-sleep) EEG in rabbits.
Epitalon is a synthetic tetrapeptide (AEDG) from Russian pineal-peptide research, heavily promoted for telomerase activation and longevity.
Apelin is an endogenous peptide and the natural ligand of the APJ receptor, a G-protein-coupled receptor closely related to the angiotensin II receptor.
Epithalamin is a polypeptide extract of bovine pineal gland, developed from the 1970s by Vladimir Khavinson and colleagues at the St Petersburg Institute of Bioregulation and…
The Khavinson peptide bioregulators are a family of very short peptides — typically two to four amino acids — developed since the 1970s at the St Petersburg Institute of…
Ranking is by evidence grade (A–F), the same ceiling shown on each compound page — not by popularity or margin. No dosing, reconstitution, or administration is given anywhere on Vallydia. See each entry for its full evidence table and legal status by region.
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This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia.