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DHHB (Uvinul A Plus)

A
lead outcome
Long-UVA (UVA-I) protection
grades vary by outcome ↓
Small molecule (non-peptide)
also called — Uvinul A Plus · diethylamino hydroxybenzoyl hexyl benzoate · hexyl diethylaminohydroxybenzoylbenzoate · DHHB · INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate
UV filter (organic)UVA-I protectionphotostablesinglet oxygen quenching

Status: reference entry — not for sale. Neutral scientific reference only. No application instructions are published here; concentration figures are regulatory ceilings and formulation ranges reported in the literature, not usage advice.

In brief

DHHB (INCI diethylamino hydroxybenzoyl hexyl benzoate, sold by BASF as Uvinul A Plus) is the modern European answer to avobenzone's central weakness. It absorbs deep in the long-UVA range with a peak at 354 nm, and unlike avobenzone it is highly photostable — it does not lose its UVA absorbance under sun exposure, so a formula built on it does not need a stabilising partner to keep working. In vitro testing found no phototoxic potential and no detectable UV-induced free radicals in filter mixtures. One widely repeated claim is wrong and worth correcting: DHHB does not photostabilise avobenzone. A 2017 study measured this directly and found no effect, with fluorescence spectroscopy showing the two interact by static quenching without altering avobenzone's excited-state lifetime — the authors concluded that a DHHB formula is more advantageous than one containing avobenzone or both together. It does stabilise triazine filters, which is a different interaction. Approved in the EU since 2005 at up to 10%; not approved in the US, which is a large part of why American sunscreens still depend on avobenzone for long-UVA protection.

Legal standing, by region
European Union
Permitted cosmetic UV filter, up to 10%

Approved in Europe in 2005; listed in Annex VI of the EU Cosmetics Regulation at a maximum of 10%, alone or in combination.

United Kingdom
Permitted cosmetic UV filter

Retained EU cosmetics framework; equivalent to the EU position.

United States
Not approved

Not an approved sunscreen active in the US. Sunscreens are regulated as OTC drugs there, and DHHB has not cleared that process — unlike bemotrizinol, which was approved in June 2026.

International
Widely permitted outside the US

In common use in European, Australian, Japanese and Korean sun care. Manufactured by BASF as Uvinul A Plus.

Evidence, by outcome
How we grade →

An honest grade per outcome — drawn from the evidence, not any catalogue. Hype and undemonstrated marketing claims grade low.

OutcomeEvidence base · effectGrade
Long-UVA (UVA-I) protection
Its peak sits close to avobenzone's useful range, which is the point: DHHB was developed as an alternative to avobenzone rather than a complement to it. Coverage is UVA-focused — it contributes little in UVB, so it is always formulated alongside UVB filters.
Absorption peak at **354 nm** — deep in the UVA-I range — with coverage across roughly 320-390 nm. Designed on benzophenone chemistry and approved in Europe in 2005 specifically as a modern UVA filter. Described in the formulation literature as probably the most representative of the newer UVA filters. · Strong protection in the long-UVA wavelengths most associated with photoageing, pigmentation and dermal matrix damage.
A
Photostability
This is the entire reason DHHB exists. Where avobenzone loses UVA absorbance through keto-enol tautomerism within the hour, DHHB does not degrade in the same way — so a DHHB-based formula does not depend on a stabilising partner filter to keep working.
Consistently reported as highly photostable across photochemical studies. In the Kawakami et al. (2017) work, DHHB was photostable in all formulations studied. Photophysical characterisation confirms a stable excited-state profile, and in filter mixtures it produced no detectable UV-induced free radicals in tested formulations. · Retains its UVA absorbance through sun exposure — the specific failure mode that limits avobenzone.
A
Photostabilising avobenzone — the common claim, and it is wrong
Worth being precise, because this is widely misstated. DHHB **does** photostabilise triazine filters, and it is a good partner in mixtures generally — its lowest excited triplet state sits higher than those of octyl methoxycinnamate and octocrylene, so it can act as a triplet energy donor. But for avobenzone specifically the effect is absent. The study authors' conclusion was that formulations containing DHHB alone should be considered **more advantageous** than those containing avobenzone, or avobenzone plus DHHB — i.e. use it *instead of*, not *with*.
Kawakami CM, Máximo LNC, Fontanezi BB, Santana da Silva R, Gaspar LR. Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations — evaluation of the photochemical behavior and photostabilizing effect. Eur J Pharm Sci. 2017;99:299-309. HPLC and spectrophotometry across multiple formulations: **DHHB did not present a photostabilizing effect on avobenzone.** Fluorescence spectroscopy showed the two interact by static quenching, and DHHB did not affect avobenzone's excited-state lifetime — Förster energy transfer, the usual singlet-singlet quenching mechanism, was judged unlikely here. That mechanistic finding explains the negative result. · No stabilising benefit for avobenzone, despite the two often being listed together.
F
Phototoxicity
Notable by comparison: in the same body of work, avobenzone-octinoxate combinations did show phototoxic potential. Degradation products matter, and a filter that does not degrade does not generate them.
In vitro phototoxicity assessed in 3T3 fibroblast cultures (Kawakami et al., 2017): combinations containing DHHB showed **no phototoxic potential**. Separately, DHHB produced no detectable UV-induced free radicals in tested filter mixtures. · No phototoxic signal in the standard in vitro model.
A
Skin binding and systemic exposure
Low binding is not the same as a full systemic-absorption dataset, and DHHB has not been through an FDA maximal-use plasma study — it is not approved in the US, so no such study exists. Its EU authorisation rests on SCCS assessment rather than on the US data programme.
DHHB is a non-bonding filter. In a skin-binding assay it showed a bound proportion of only **3%**, versus 76% for a purpose-designed skin-bonding comparator. Molecular weight 397.5 g/mol; oil- and ethanol-soluble. · Sits on the surface rather than binding into skin.
Regulatory status
This is the same regulatory gap that kept bemotrizinol out of the US until June 2026 — and DHHB has not followed. As of writing it remains unavailable to US formulators, which is part of why American sunscreens have leaned on avobenzone for long-UVA coverage. Whether it follows bemotrizinol through the FDA process is an open question.
Approved in the **EU since 2005**, permitted at up to **10%** (alone or in combination with other UV filters). Listed in Annex VI of the EU Cosmetics Regulation. **Not approved in the United States.** · Standard in European, Australian and Asian sun care; absent from US products.
Disclosure

Vallydia sells its own cosmetic serums, and some ingredients graded here belong to the same categories as those products. Grades are drawn from the published evidence by the method we publish, and applied to our own ingredients on the same terms — our copper-peptide serum is graded no more kindly than the peptides it competes with. We disclose the interest so you can weigh it.

Trade names shown here (for example Matrixyl, Argireline, Syn-Ake) are the property of their respective owners and are used only to identify the ingredient under discussion. Their appearance implies no affiliation with, or endorsement by, the proprietor.

Evidence changes

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Identity

DHHB — INCI name diethylamino hydroxybenzoyl hexyl benzoate, marketed by BASF as Uvinul A Plus — is an oil-soluble organic UVA filter, designed on classical benzophenone chemistry and approved in Europe in 2005.

It exists for one reason: avobenzone's instability. Avobenzone has excellent long-UVA absorption and loses it rapidly under sunlight; DHHB was developed to occupy the same spectral territory without the same failure mode.

⚠️ Not to be confused with DHAB (diethylamino hydroxybenzoyl ascorbyl benzoate), a skin-bonding derivative appearing in related patent literature — a different substance.

How it works

DHHB absorbs with a peak at 354 nm, deep in the UVA-I range, with useful coverage across roughly 320-390 nm. Its contribution in UVB is minimal, so it is always paired with UVB filters — it is a specialist, not a broad-spectrum filter in the way bemotrizinol or zinc oxide are.

Its defining property is that its excited state resolves harmlessly. Where avobenzone's UV absorption drives a tautomeric shift that destroys its own UVA absorbance, DHHB returns to ground state without degrading — reported as photostable across all formulations in the published photochemical work, with no detectable UV-induced free radicals in filter mixtures. It also quenches singlet oxygen, which is relevant to reducing UV-induced oxidative stress rather than to UV filtering as such.

It binds skin very little — a bound proportion of about 3% in a skin-binding assay, against 76% for a comparator designed to bond — so it stays where it is applied.

The correction: DHHB does not stabilise avobenzone

This is the most useful thing in this entry, because the opposite is widely assumed. Since DHHB is photostable and avobenzone is not, and since both are UVA filters, it seems natural that pairing them would help. It does not.

Kawakami et al. (2017) tested this directly across multiple sunscreen formulations using HPLC and spectrophotometry. The result: DHHB did not present a photostabilising effect on avobenzone. Fluorescence spectroscopy explained why — the two interact by a static quenching mechanism, and DHHB does not affect avobenzone's excited-state lifetime. Förster resonance energy transfer, the mechanism usually responsible for singlet-singlet quenching, was judged unlikely in this system. In other words, DHHB never engages avobenzone's excited singlet state, which is the state that needs quenching.

The authors' conclusion followed directly: formulations containing DHHB alone should be considered more advantageous than those containing avobenzone, or avobenzone and DHHB together.

What DHHB does stabilise is the triazine filter class — a different interaction, and one reported positively in the photokinetics literature. Its lowest excited triplet state sits higher than those of octyl methoxycinnamate and octocrylene, so it can act as a triplet energy donor in mixtures. The stabilising ability is real; it simply does not extend to avobenzone.

The practical reading for anyone looking at an ingredient list: DHHB and avobenzone appearing together is not a photostability strategy. It may be a coverage decision, but the avobenzone in that formula still needs octocrylene, bemotrizinol or another genuine stabiliser to survive the day.

Reading the evidence honestly

Why grade A. Strong long-UVA absorption, genuine photostability, no phototoxic signal in the standard in vitro model, no detectable UV-induced free radicals, minimal skin binding, and two decades of European use. As a UVA filter it does its job without the caveat that dominates avobenzone's entry.

What the grade does not claim. DHHB is not broad-spectrum — it needs UVB partners, and a product is only as good as its whole filter system. Its safety file rests on SCCS assessment, not on the US maximal-use plasma programme, simply because it has never been through the FDA process; that is an absence of data rather than a concern, but it is an absence. And there is far less published work on it than on avobenzone or the mineral filters — it is a well-regarded filter with a moderate literature, not a heavily interrogated one.

The regulatory asymmetry is the practical story. DHHB has been standard in European, Australian, Japanese and Korean sunscreens for two decades while remaining unavailable in the United States. Bemotrizinol finally cleared the FDA in June 2026, after two decades pending; DHHB has not. That gap — not chemistry — is why American long-UVA protection has rested so heavily on avobenzone and zinc oxide.

Chemical identifiers

Cross-reference identifiers for the authoritative external databases — not a recipe, and nothing about how to use it.

PubChem CID10111431
InChIKeyFDATWRLUYRHCJE-UHFFFAOYSA-N
SMILESCCCCCCOC(=O)C1=CC=CC=C1C(=O)C2=C(C=C(C=C2)N(CC)CC)O

via PubChem exact-name match (diethylamino hydroxybenzoyl hexyl benzoate / Uvinul A Plus, CID 10111431; C24H31NO4, ~397.5 g/mol); CAS 302776-68-7. Distinct from DHAB (diethylamino hydroxybenzoyl ascorbyl benzoate), the ascorbyl skin-bonding derivative in related patent literature. · high confidence

Sources — 5 cited
01Kawakami CM, Máximo LNC, Fontanezi BB, Santana da Silva R, Gaspar LR. Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations — evaluation of the photochemical behavior and photostabilizing effect. Eur J Pharm Sci. 2017;99:299-309.
02Shamoto Y, et al. Photophysical properties of hexyl diethylaminohydroxybenzoylbenzoate (Uvinul A Plus), a UV-A absorber. Photochem Photobiol Sci.
03Lhiaubet-Vallet V, Marin M, Jimenez O, Gorchs O, Trullas C, Miranda MA. Filter-filter interactions: photostabilization, triplet quenching and reactivity with singlet oxygen. Photochem Photobiol Sci. 2010;9:552-558.
04Sohn M, et al. Photokinetics of oil-soluble 1,3,5-triazine UV filters in combination with butyl methoxydibenzoylmethane or with diethylamino hydroxybenzoyl hexyl benzoate.
05Scientific Committee on Consumer Safety (SCCS) — assessment underpinning the EU Annex VI listing at 10%.
Updated 2026-07-25 (the open question is whether DHHB follows bemotrizinol through the US approval process — re-check FDA status)

Grades reflect the published evidence, not our interest. No dosing, reconstitution, or administration is published for research compounds — that restraint is deliberate.

Related compounds
AvobenzoneB
Small molecule (non-peptide)
Bemotrizinol (Tinosorb S)A
Small molecule (non-peptide)
OctocryleneC
Small molecule (non-peptide)
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