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Bemotrizinol (Tinosorb S)

A
lead outcome
Broad-spectrum UVA + UVB protection
grades vary by outcome ↓
Small molecule (non-peptide)
also called — BEMT · Tinosorb S · Parsol Shield · Escalol S · bis-ethylhexyloxyphenol methoxyphenyl triazine · INCI: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine
UV filter (organic)broad-spectrumphotostablephotostabiliser

Status: reference entry — not for sale. Neutral scientific reference only. No application instructions are published here; concentration figures are regulatory or formulation ranges reported in the literature, not usage advice.

In brief

Bemotrizinol (INCI bis-ethylhexyloxyphenol methoxyphenyl triazine, sold as Tinosorb S, Parsol Shield or Escalol S) is a triazine-based organic UV filter and, on the evidence, one of the best available. It is genuinely broad-spectrum from a single molecule, with two absorption peaks at roughly 310 nm and 340 nm covering the full UVB and UVA range; it is exceptionally photostable, retaining 98.4% intact after 50 MEDs; it stabilises other filters, reportedly preserving up to 100% of avobenzone in some combinations; and it shows minimal skin absorption — in a maximal-use trial of a 6% formulation, only 13 of 299 plasma samples had quantifiable levels, against the older organic filters that all exceeded the FDA's 0.5 ng/mL threshold. Used in Europe, Australia and Asia since around 1999-2000, it is a large part of why those markets have lighter, more elegant sunscreens. In June 2026 the FDA approved it (Final Order OTC000039, Monograph M020, GRASE, up to 6%) — the first new sunscreen active added to the US monograph since the late 1990s. That approval also breaks the marketing shorthand that mineral filters are GRASE and chemical filters are not: bemotrizinol is an organic filter with GRASE standing.

Legal standing, by region
European Union
Permitted cosmetic UV filter

Listed in Annex VI of the EU Cosmetics Regulation. In use in Europe since around 1999-2000 under trade names Tinosorb S, Parsol Shield and Escalol S.

United Kingdom
Permitted cosmetic UV filter

Retained EU cosmetics framework; equivalent to the EU position.

United States
OTC drug — GRASE, up to 6% (approved June 2026)

FDA Final Administrative Order OTC000039 added bemotrizinol to OTC Sunscreen Monograph M020 as GRASE at up to 6% for ages 6 months and older (Federal Register, 10 June 2026; effective 9 August 2026). The first new sunscreen active added to the US monograph since the late 1990s; the proposed order was issued in December 2025. US-permitted concentrations and formulation rules differ from the EU — an existing European formula cannot simply be moved across.

International
Widely permitted

Long-standing use in Australia, Japan, Korea and much of Asia. Developed by Ciba Specialty Chemicals, now marketed by BASF as Tinosorb S; also sold as Parsol Shield (DSM) and Escalol S.

Evidence, by outcome
How we grade →

An honest grade per outcome — drawn from the evidence, not any catalogue. Hype and undemonstrated marketing claims grade low.

OutcomeEvidence base · effectGrade
Broad-spectrum UVA + UVB protection
One of very few organic filters that covers the full range alone — a property otherwise found mainly in zinc oxide. It is still a filter, not a routine: quantity applied and reapplication govern real-world protection.
Bemotrizinol is a triazine-based UV absorber with **two absorption peaks, approximately 310 nm and 340 nm**, covering the entire UVB and UVA range. In use in Europe, Australia and parts of Asia since around 1999-2000, and described in the FDA's own review as showing strong UVA and UVB protection. · True broad-spectrum protection from one organic filter, including the long-UVA wavelengths where most organic filters are weak.
A
Photostability
Photostability is not durability in wear. Bemotrizinol can still be removed by towels, clothing, water and physical activity like any other filter, and no sunscreen offers indefinite protection.
Exceptional and well quantified: **98.4% remains intact after 50 MEDs** (minimal erythemal doses). This is the property that made it a global benchmark. · Protection does not meaningfully decline through photodegradation over realistic sun exposure.
A
Photostabilising other filters
This matters most in the US, where avobenzone has been the only widely used long-UVA organic filter and octocrylene the main stabilising option. Bemotrizinol offers a second, more effective route.
Well documented and cited in the FDA's scientific review supporting the approval order. Foundational reference: Chatelain & Gabard (2001) on the photostabilisation of avobenzone and octinoxate by bemotrizinol. A 2025 toxicology review is reported to describe bemotrizinol preserving up to 100% of the avobenzone in some studied combinations (see the citation note). · Keeps photo-unstable filters — avobenzone above all, and octinoxate — working across sustained UV exposure.
A
Skin absorption and irritation
This is the sharpest contrast with the older organic filters. In the FDA's 2020 maximal-use study, avobenzone, oxybenzone, octocrylene and ecamsule all exceeded the 0.5 ng/mL threshold; bemotrizinol was largely undetectable under comparable conditions. Its large molecular size (627.8 g/mol) is the likely reason. As always: absorption is not itself harm — but avoiding the question entirely is a genuine advantage.
Per the FDA's review, bemotrizinol shows minimal absorption through the skin and low rates of irritation. A preliminary trial in healthy adults found that maximal application of a formulation containing 6% bemotrizinol did not result in meaningful systemic exposure — only 13 of 299 plasma samples showed quantifiable bemotrizinol. · Very low systemic exposure even under maximal-use conditions.
A
Regulatory status — newly approved in the US
Note what this changes about the usual framing: bemotrizinol is an **organic filter with GRASE status**, which breaks the convenient "mineral = GRASE, chemical = Category III" shorthand used in marketing. Category III was always about data submitted, and this approval demonstrates it — the data were eventually submitted and reviewed. Practical caveat: US formulations are not simply European formulations relabelled; permitted concentrations and the surrounding filter system differ by market.
In **June 2026** the FDA finalised Administrative Order **OTC000039**, adding bemotrizinol to the OTC Sunscreen Monograph **M020** as a **GRASE** ingredient at up to **6%** for ages 6 months and older — the **first new sunscreen active added to the US monograph in more than two decades** (published in the Federal Register on 10 June 2026; effective 9 August 2026). The proposed order was issued in December 2025. Long established in the EU (Annex VI), Australia and Asia. · Now permitted on both sides of the Atlantic, with GRASE standing in the US.
A
Cosmetic elegance
This is not a cosmetic footnote. Sunscreen only works if it is worn, and cast and greasiness are leading reasons people stop — particularly on medium and deep skin tones. Dermatology commentary on the approval frames improved elegance as an **adherence** benefit, which is the point.
Oil-soluble and used at low percentages — patent literature describes typical inclusion at roughly 0.5-5%, often 0.7-2% (the US monograph permits up to 6%). It is associated with the lighter textures characteristic of European, Korean, Japanese and Australian sunscreens. · No white cast; light, wearable textures that layer under makeup.
A
Disclosure

Vallydia sells its own cosmetic serums, and some ingredients graded here belong to the same categories as those products. Grades are drawn from the published evidence by the method we publish, and applied to our own ingredients on the same terms — our copper-peptide serum is graded no more kindly than the peptides it competes with. We disclose the interest so you can weigh it.

Trade names shown here (for example Matrixyl, Argireline, Syn-Ake) are the property of their respective owners and are used only to identify the ingredient under discussion. Their appearance implies no affiliation with, or endorsement by, the proprietor.

Evidence changes

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Identity

Bemotrizinol — INCI name bis-ethylhexyloxyphenol methoxyphenyl triazine, abbreviated BEMT, and sold as Tinosorb S (BASF), Parsol Shield (DSM) and Escalol S — is an oil-soluble, triazine-based organic UV filter. It was developed by Ciba Specialty Chemicals, later acquired by BASF.

⚠️ Do not confuse with bisoctrizole (Tinosorb M) — a different filter with a nearly identical trade name. The two are often mentioned together and are not interchangeable.

A note on why this entry exists now: for most of its life, bemotrizinol was the standard example of the gap between European and American sun care — widely used abroad since around 1999-2000, unavailable in the US. That changed in June 2026.

How it works

Bemotrizinol absorbs across the full ultraviolet range through two absorption peaks, at approximately 310 nm and 340 nm. That dual-peak profile is what makes it broad-spectrum in a single molecule: 310 nm sits in UVB, 340 nm in UVA, and the absorption band is wide enough to bridge them and extend into long UVA.

Its second defining property is photostability. Where avobenzone loses much of its UVA absorbance within an hour of sun exposure through tautomerisation, bemotrizinol retains 98.4% intact after 50 minimal erythemal doses — an exposure far beyond a normal day outdoors. It does not merely survive UV; it can absorb the energy that would otherwise degrade neighbouring filters, which is why it doubles as a photostabiliser for avobenzone and octinoxate.

Its molecular size (around 628 g/mol) is also relevant: large molecules cross the stratum corneum poorly, which is the likely explanation for its very low systemic absorption.

The 2026 US approval, and what it actually means

In June 2026, the FDA finalised Administrative Order OTC000039, adding bemotrizinol to the OTC Sunscreen Monograph M020 as a GRASE ingredient at up to 6%, for ages 6 months and older (published in the Federal Register on 10 June 2026, effective 9 August 2026; the proposed order was issued in December 2025). It is the first new sunscreen active added to the US monograph since the late 1990s. Bemotrizinol had been available abroad for over two decades and pending in the US since the early Time-and-Extent-Application era — the 2026 order came through a manufacturer request under the newer CARES Act pathway.

Three implications worth separating.

For US formulation. American formulators have been working with a short filter list, in which avobenzone was effectively the only widely used long-UVA organic option and octocrylene the main way to keep it stable. Bemotrizinol adds a filter that is broad-spectrum, photostable, and itself a stabiliser. Dermatology commentary frames the likely result as lighter, more wearable US sunscreens — which matters less as luxury than as adherence, since the sunscreen people actually wear outperforms the one they avoid.

For the "mineral vs chemical" framing. This approval quietly dismantles a common marketing shorthand. The claim that mineral filters are GRASE and chemical filters are not was always a description of data submitted, not of safety established — and bemotrizinol is now an organic filter with full GRASE standing. The distinction was regulatory history, not chemistry.

A practical caution. Existing European formulas cannot simply be relabelled for the US market: permitted concentrations, the surrounding filter system and monograph requirements differ. Expect US products containing bemotrizinol to appear gradually rather than immediately, and expect the same product name to carry different filter systems in different markets — always check the actual ingredient list of the version you are buying.

Reading the evidence honestly

Bemotrizinol earns grade A, which in this register is uncommon, so it is worth being precise about why — and about what an A does not mean.

What is genuinely strong. Full-range coverage from one molecule; quantified photostability (98.4% after 50 MEDs) that is exceptional rather than merely adequate; documented ability to preserve other filters, reportedly up to 100% of avobenzone in some combinations; minimal systemic absorption, with only 13 of 299 plasma samples quantifiable in a maximal-use trial of a 6% formulation; low irritation rates in the FDA's review; and more than two decades of real-world use across Europe, Australia and Asia before US approval.

What an A does not mean. It does not mean bemotrizinol is necessary — well-formulated sunscreens without it protect perfectly well, and zinc oxide covers a similar spectrum. It does not make older filters unsafe; avobenzone with proper stabilisation remains effective, and the FDA's absorption findings for organic filters have not been shown to correspond to harm. And it does not change the fundamentals: the amount applied and the frequency of reapplication determine real-world protection more than the choice of filter. Most people apply well under the quantity used in SPF testing, and no filter compensates for that.

One honest limitation of this entry. The US approval is very recent. American product availability, real-world formulation choices and any post-approval findings are still developing.

Chemical identifiers

Cross-reference identifiers for the authoritative external databases — not a recipe, and nothing about how to use it.

PubChem CID135487856
InChIKeyXVAMCHGMPYWHNL-UHFFFAOYSA-N
SMILESCCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)OC)C4=C(C=C(C=C4)OCC(CC)CCCC)O)O

via PubChem exact-name match — both "bemotrizinol" and the INCI name "Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine" resolve to CID 135487856 (C38H49N3O5, ~627.8 g/mol); CAS 187393-00-6. NOTE: the frequently-cited CID 11954320 does NOT match the current PubChem record and was not used. Distinct from bisoctrizole (Tinosorb M), a different filter with a similar trade name. · high confidence

Sources — 5 cited
01US Food and Drug Administration. Final Administrative Order OTC000039 — bemotrizinol added to OTC Sunscreen Monograph M020 as GRASE (up to 6%). Federal Register, 10 June 2026 (doc 2026-11578); effective 9 August 2026.
02Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74(3):401-406.
03Comprehensive toxicology review of bemotrizinol. Crit Rev Toxicol. 2025 — reported to describe preservation of up to 100% of avobenzone in some combinations.
04The Medical Letter. Sunscreens — preliminary trial data on maximal application of 6% bemotrizinol (13 of 299 plasma samples quantifiable).
05Seité S, et al. Sunscreens with an absorption maximum of ≥360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1 and interleukin-6 in human dermal fibroblasts. Photochem Photobiol Sci. 2006;5(3):275-282.
Updated 2026-07-25 (very recent — the FDA order was finalised in June 2026 (effective 9 August 2026) and US products are only beginning to reformulate; re-check which US products actually contain it and whether further filters follow.)

Grades reflect the published evidence, not our interest. No dosing, reconstitution, or administration is published for research compounds — that restraint is deliberate.

Related compounds
AvobenzoneB
Small molecule (non-peptide)
OctocryleneC
Small molecule (non-peptide)
Zinc OxideA
Small molecule (non-peptide)
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