The register's cleanest honest-debunk: a fat-loss peptide that was properly tested in humans — and failed. Three points define this entry: (1) unlike most gray-market compounds (F because untested), AOD-9604 is F because it was tested and didn't work — it ran six human trials in 900+ people and miss
AOD-9604 is a synthetic fragment of growth hormone's fat-burning tail (residues 176-191, stabilised with a tyrosine and a disulfide bridge), engineered by Metabolic Pharmaceuticals in the 1990s to isolate GH's lipolytic effect without its growth/IGF-1/glucose effects. On the design goal it succeeded — it doesn't raise IGF-1 or disturb blood sugar, and its safety across six trials in 900+ people was reassuring. But on the thing that matters, it failed: a pivotal Phase 2b trial in 500+ obese adults missed its primary weight-loss endpoint, the effect was too small to be clinically meaningful, and Metabolic Pharmaceuticals abandoned it in 2007. This is the register's clearest example of an honest debunk — not "unproven because nobody studied it," but "studied properly and it didn't work." It's still sold everywhere for fat loss; the single most useful fact a reference can carry is that it flunked its own pivotal trial. It's also not FDA-approved, FDA-flagged as a risk-bearing bulk substance, and WADA-banned in sport.
not approved; investigational/research chemical; not a cosmetic.
not FDA-approved for any use; listed by the FDA as a bulk drug substance that may present safety risks (i.e. flagged, not endorsed).
An honest grade per outcome — drawn from the evidence, not any catalogue. Hype and undemonstrated marketing claims grade low.
A credentialed reviewer (PharmD / PhD / MD) will be named before this entry is finalised. Until then, treat it as a working draft. Last updated July 2026 (status stable — a failed/abandoned obesity program; unlikely to change absent a new indication with real data).
Grades reflect the published evidence, not our interest. No dosing, reconstitution, or administration is published for research compounds — that restraint is deliberate.
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