Region — US. Neutral scientific reference — not offered for sale here.
Set region
Vallydia
ExploreShopToolsJournalTrustSearch ⌕
Explore  /  Semaglutide
Research reference — not for sale

Semaglutide

A
best evidence
Peptide
also called — semaglutide · GLP-1 receptor agonist
metabolictype-2 diabetesobesity / weightcardiovascular / kidney (all approved)

Reference entry — explicitly NOT a sellable lane. Semaglutide is a patented, FDA-approved blockbuster prescription drug; it cannot be sold here as a cosmetic or "research" peptide, and compounded copies are now largely prohibited (below). It sits in the register for reference and completeness — the

In brief

Semaglutide is a GLP-1 receptor agonist and one of the most-prescribed medicines in the world — FDA-approved for type-2 diabetes (Ozempic), obesity (Wegovy) and oral T2D (Rybelsus), with expanded cardiovascular and kidney indications. Its efficacy rests on one of the largest Phase 3 programmes in modern medicine (grade A). The compounded version that flooded the market is now largely prohibited following the February-2025 shortage resolution.

Legal standing, by region
European Union
Approved / prescription

approved (EMA) as Ozempic / Wegovy / Rybelsus.

United States · your region
Approved / prescription

FDA-approved across multiple indications (Novo Nordisk brands only). Compounding: the injection shortage was declared resolved on 21 Feb 2025; the 503A/503B compounder phase-out deadlines have passed, so compounded semaglutide is now largely prohibited (narrow patient-specific exceptions aside). Gray-market and counterfeit "semaglutide" is unapproved and a documented safety risk.

International
widely approved

widely approved.

Evidence, by outcome

An honest grade per outcome — drawn from the evidence, not any catalogue. Hype and undemonstrated marketing claims grade low.

OutcomeEvidence base · effectGrade
Type-2 diabetes glycemic control
SUSTAIN Phase 3; FDA-approved · Robust HbA1c reduction
A
Chronic weight management (obesity)
Effect wanes if stopped; GI tolerability
STEP Phase 3 (~15% subQ); OASIS (oral); FDA-approved · Substantial weight loss
A
Cardiovascular risk reduction
SELECT (Wegovy), SOUL (oral); FDA-approved · Reduced major CV events
A
Kidney (T2D + CKD)
FLOW; FDA-approved (2025) · Reduced eGFR decline / ESKD / CV death
A
Safety
GI effects (nausea/vomiting/diarrhea); labeled risks; requires clinical oversight
Large trials + post-marketing · Well-characterised

Identity an acylated GLP-1 analog — a ~31-amino-acid peptide (< 40 aa → peptide) based on human GLP-1(7-37) with substitutions plus a C18 fatty-diacid chain that binds albumin, giving a long half-life (once-weekly injection; also an oral tablet formulation). ## Mechanism (as proposed) a GLP-1 receptor agonist — enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite centrally → glycemic control and weight loss.

Sources — 1 cited
01SUSTAIN, STEP, SELECT, FLOW, SOUL, OASIS Phase 3 programmes; FDA prescribing information (Ozempic/Wegovy/Rybelsus); FDA Declaratory Order resolving the semaglutide shortage (Feb 2025).
Review status
Not yet reviewed

A credentialed reviewer (PharmD / PhD / MD) will be named before this entry is finalised. Until then, treat it as a working draft. Last updated July 2026.

Grades reflect the published evidence, not our interest. No dosing, reconstitution, or administration is published for research compounds — that restraint is deliberate.

Related compounds
TirzepatideA
Peptide
LiraglutideA
Peptide
RetatrutideB
Peptide
Explore by goal
Metabolic
Vallydia

A neutral reference and a lawful-lane shop. Registered in Spain. Information for those who seek it — never promotion.

Region — United States
ExploreRegisterCategoriesTrust & COA
ShopCosmetic peptidesJournal
TermsPrivacyCookiesReturnsShippingImprint

This site provides neutral scientific reference and sells only products lawful in your region. Nothing here is medical advice, a recommendation, or an offer to supply unapproved medicines. No dosing or administration is published for research compounds. Cosmetic peptides per Regulation (EC) 1223/2009. Unapproved injectable peptides are neither sold nor advertised in the EU (Directive 2001/83/EC, Title VIII). © 2026 Vallydia SL — Registered in Spain.

Semaglutide (Ozempic / Wegovy / Rybelsus) — evidence & status · Vallydia